Nicholls J M, Pittaluga S, Chung L P, So K C
Department of Pathology, University of Hong Kong.
Pathology. 1994 Apr;26(2):94-8. doi: 10.1080/00313029400169281.
We reviewed 30 cases of carcinoma of the tonsil and classified them as squamous cell carcinoma, non-keratinizing differentiated carcinoma and non-keratinizing undifferentiated carcinoma. Five cases of non-keratinizing undifferentiated carcinoma were identified, and these, together with 5 cases of squamous cell carcinoma, were studied for the presence of Epstein-Barr virus by in situ hybridization using early RNA (EBERs) as probes. All cases of squamous cell carcinoma were negative for EBER and only one of the 5 cases of non-keratinizing undifferentiated carcinoma was positive. As a positive control we used a case of a primary nasopharyngeal carcinoma with extension to the tonsil. Though the tonsil and nasopharynx share similar anatomical and immunological features, we conclude that in the majority of cases EBV is not demonstrable in tonsillar carcinomas.
我们回顾了30例扁桃体癌病例，并将其分为鳞状细胞癌、非角化性分化癌和非角化性未分化癌。确定了5例非角化性未分化癌病例，并将这些病例与5例鳞状细胞癌病例一起，以早期RNA（EBERs）为探针，通过原位杂交研究爱泼斯坦-巴尔病毒（EBV）的存在情况。所有鳞状细胞癌病例的EBER均为阴性，5例非角化性未分化癌病例中只有1例为阳性。作为阳性对照，我们使用了1例原发鼻咽癌累及扁桃体的病例。尽管扁桃体和鼻咽具有相似的解剖学和免疫学特征，但我们得出结论，在大多数扁桃体癌病例中无法检测到EBV。
