Leung S Y, Yuen S T, Ho C M, Kwong W K, Chung L P
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
J Clin Pathol. 1998 Aug;51(8):602-5. doi: 10.1136/jcp.51.8.602.
To examine the association of Epstein-Barr virus (EBV) with carcinoma of the ear.
Five non-keratinising squamous cell carcinomas and two undifferentiated carcinomas of the ear were examined. In situ hybridisation was used to localised EBV-encoded RNAs (EBER). Immunohistochemical methods to detect LMP-1 and EBNA2 were performed in the EBER positive cases.
Two cases were EBER positive, including one non-keratinising and one undifferentiated carcinoma. Both showed identical morphology to those arising from the nasopharynx, with abundant lymphoid stroma. They were both negative for LMP-1 and EBNA2.
EBV associated carcinoma with the morphology of lymphoepithelioma can also arise from the middle ear.
研究爱泼斯坦-巴尔病毒（EBV）与耳部癌的关联。
对5例非角化性鳞状细胞癌和2例耳部未分化癌进行检查。采用原位杂交法定位EBV编码的RNA（EBER）。对EBER阳性病例进行免疫组织化学方法检测LMP-1和EBNA2。
2例EBER阳性，包括1例非角化性癌和1例未分化癌。两者形态与鼻咽癌相同，伴有丰富的淋巴间质。两者LMP-1和EBNA2均为阴性。
具有淋巴上皮瘤形态的EBV相关癌也可发生于中耳。
