[Clinical evaluation of norfloxacin preparation in treatment of bacterial infections of the urinary tract in patients with various kidney diseases].

Norfloxacin (Nolicin Krka) has been administered to 22 patients with urinary tract infections. The drug has been administered in daily dose of 800 mg for 10 days. An ultimate result has been evaluated after 3 months. Sterile urine cultures or less that 10,000 cells per millilitre have been achieved in 13 (59%) patients. Relapse of infection with other strain have been found in 9 (41%) patients. No adverse reactions which required cessation of therapy have been noted. An examination of isolates sensitivity to norfloxacin in vitro has shown that the drug is active against Gram-negative Enterobacteriaceae, P. aeruginosa, and Gram-positive staphylococci. Various strains of streptococci have been insensitive to norfloxacin. The obtained results suggest that norfloxacin is useful antibacterial agent and produces both clinical and bacteriological improvement in about 60% of patients with urinary tract infections.