Boerema J B, van Saene H K
Scand J Infect Dis Suppl. 1986;48:20-6.
Twenty-four patients with complicated urinary tract infections were treated with norfloxacin for three months. Group I (n = 12), received 400 mg b.i.d. during three months and Group II (n = 12) received 400 mg b.i.d. during one month, followed by 400 mg as a single dose for two months. Most of the infections (67%), were due to Pseudomonas spp. A bacteriological cure rate of 75% (9/12) and 92% (11/12) in groups I and II, respectively, was achieved after three months therapy. One month after cessation of therapy patients were free of their initial infection in 75% (9/12) and 83% (10/12), respectively. Clinical cure was achieved in 75% of the patients in both groups. This remained the case in group I after cessation of treatment. In group II, 50% remained free of symptoms one month post-therapy. Both clinical and laboratory adverse reactions were minor and none of the patients discontinued treatment due to side effects. Norfloxacin therapy was effective in the long term treatment of chronic recurrent infections in patients with severe urological conditions. Prevention of relapse or reinfection from the primary endogenous faecal reservoirs (Enterobacteriaceae), was probably due to the high effect of norfloxacin against these organisms. The relatively good effect on pseudomonas infection in this group of patients, was probably due to a high concentration of norfloxacin in the urine.
24例复杂性尿路感染患者接受诺氟沙星治疗3个月。第一组（n = 12），在3个月内每日2次，每次400mg；第二组（n = 12），在1个月内每日2次，每次400mg，随后2个月每日单次服用400mg。大多数感染（67%）由假单胞菌属引起。治疗3个月后，第一组和第二组的细菌学治愈率分别为75%（9/12）和92%（11/12）。治疗停止1个月后，患者分别有75%（9/12）和83%（10/12）的初始感染已消除。两组中75%的患者实现了临床治愈。治疗停止后第一组仍保持这种情况。在第二组中，治疗后1个月50%的患者无症状。临床和实验室不良反应均较轻微，没有患者因副作用而停止治疗。诺氟沙星治疗对患有严重泌尿系统疾病患者的慢性复发性感染的长期治疗有效。预防来自主要内源性粪便菌库（肠杆菌科）的复发或再感染，可能是由于诺氟沙星对这些微生物的高效作用。该组患者对假单胞菌感染的相对良好疗效，可能是由于尿液中诺氟沙星的高浓度。
