Belis J A, Curley R M, Lang C M
Division of Urology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.
Pharmacology. 1996 Jul;53(1):66-70. doi: 10.1159/000139416.
The spontaneously diabetic adult male Abyssinian-Hartley guinea pig develops bladder hypertrophy and voiding dysfunction. In contrast to animals with chemically induced diabetes, this animal demonstrates changes in bladder function in the absence of diuresis. The diabetic guinea pigs void a total daily volume similar to that of control animals, but have a greater mean volume per void and a longer interval between voiding. Cystometry demonstrates that the diabetic guinea pig produces greater intraluminal bladder pressure, but maintains voiding pressure for a shorter interval. A significantly decreased contractile response of the diabetic bladder base may be responsible for the bladder hypertrophy and voiding dysfunction.
成年雄性自发性糖尿病阿比西尼亚-哈特利豚鼠会出现膀胱肥大和排尿功能障碍。与化学诱导糖尿病的动物不同，这种动物在没有多尿的情况下就表现出膀胱功能的变化。糖尿病豚鼠每日总尿量与对照动物相似，但每次排尿的平均尿量更大，排尿间隔时间更长。膀胱测压显示，糖尿病豚鼠膀胱腔内压力更高，但维持排尿压力的时间更短。糖尿病膀胱底部收缩反应显著降低可能是导致膀胱肥大和排尿功能障碍的原因。
