Rustomjee T, Wagner A, Orton E C
Department of Clinical Sciences, Colorado State University, Fort Collins.
Vet Surg. 1994 Jul-Aug;23(4):307-10. doi: 10.1111/j.1532-950x.1994.tb00489.x.
Thoracotomy in dogs often is associated with lower than expected arterial oxygen tensions (PaO2). Pulmonary collapse from opening the thoracic cavity is likely to be responsible for decreased PaO2 during thoracotomy. To examine whether positive end-expiratory pressure (PEEP) is beneficial to dogs undergoing thoracotomy, PaO2 and hemoglobin saturation (SaO2) were measured in dogs randomly assigned to receive 5 cm of H2O PEEP (n = 7) or no PEEP (n = 9). During surgery in both groups of dogs, PaO2 progressively decreased (P < .001), but the decrease in PaO2 was significantly less in the PEEP group (P = .027). In both groups, PaO2 did not decrease enough to have a substantial effect on SaO2. Furthermore, application of PEEP during thoracotomy did not prevent moderate hypoxemia after surgery and discontinuation of PEEP. Application of 5 cm of H2O PEEP seems to attenuate the decrease in PaO2 observed in dogs undergoing thoracotomy, but routine application of PEEP does not seem justified.
犬类开胸手术常伴有低于预期的动脉血氧分压（PaO2）。开胸导致的肺萎陷可能是开胸手术期间PaO2降低的原因。为了研究呼气末正压通气（PEEP）对接受开胸手术的犬类是否有益，对随机分配接受5 cm H2O PEEP（n = 7）或不接受PEEP（n = 9）的犬类测量了PaO2和血红蛋白饱和度（SaO2）。在两组犬类的手术过程中，PaO2逐渐降低（P <.001），但PEEP组的PaO2降低幅度明显较小（P =.027）。在两组中，PaO2降低幅度均不足以对SaO2产生实质性影响。此外，开胸手术期间应用PEEP并不能预防术后停止PEEP后的中度低氧血症。应用5 cm H2O PEEP似乎可减轻开胸犬类中观察到的PaO2降低，但常规应用PEEP似乎并无必要。
