[7,12-二甲基苯并(a)蒽5,6-氧化物对小鼠的致癌作用]
[Carcinogenic effect of 7,12-dimethylbenz(a)anthracene 5,6-oxide in mice].
作者信息
Chouroulinkov I, Gentil A, Lasne C
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Jul 21;281(2-3):207-10.
PMID:809205
Abstract
The comparative carcinogenic activities of 7,12-dimethylbenz(a)anthracene 5,6-oxide (DMBA-5,6-oxide) and 7,12-dimethylbenz(a)anthracene (DMBA) to skin and subcutaneous tissue were studied. It was found that DMBA-5,6-oxide was less carcinogenic to both the skin and subcutaneous tissue, than DMBA. Moreover it does not show any significant initiating acitivity. The results are discussed.
摘要
研究了7,12-二甲基苯并(a)蒽5,6-氧化物（DMBA-5,6-氧化物）和7,12-二甲基苯并(a)蒽（DMBA）对皮肤和皮下组织的相对致癌活性。发现DMBA-5,6-氧化物对皮肤和皮下组织的致癌性均低于DMBA。此外，它没有显示出任何显著的引发活性。对结果进行了讨论。
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