Wilcox A J, Skjaerven R, Irgens L M
Epidemiology Branch, NIEHS, Research Triangle Park, NC 27709.
Am J Public Health. 1994 Sep;84(9):1463-7. doi: 10.2105/ajph.84.9.1463.
The hypothesis was tested that unfavorable social conditions are associated with poor perinatal survival through direct effects on pregnancy or, more indirectly, through effects on mothers born under such conditions. The occupation of Norway by Nazi Germany was used as a period of social hardship.
Data from Norwegian vital statistics and the Medical Birth Registry were used to describe perinatal mortality during World War II and also a generation later, among babies born to mothers who had themselves been born during the war. Logistic regression was used to identify a possible cohort effect among mothers born in 1940 through 1944 compared with mothers born before or after that period.
Harsh conditions in Norway during the occupation increased childhood mortality. However, perinatal mortality declined during that period. Likewise, no adverse effect was seen on the survival of babies born to mothers who had themselves been born during the war (odds ratio = 1.00; 95% confidence interval = 0.96, 1.04).
We find no evidence that wartime conditions in Norway impaired perinatal survival, either directly or through an effect on women born during the war. These data underscore how little is known about the ways that social conditions influence perinatal mortality.
对以下假设进行了检验,即不利的社会状况通过对妊娠的直接影响,或更间接地通过对在这种状况下出生的母亲的影响,与围产期存活率低相关。纳粹德国对挪威的占领被用作一段社会艰难时期。
利用挪威人口动态统计数据和医疗出生登记数据来描述第二次世界大战期间以及一代人之后,即那些母亲本人在战争期间出生的婴儿的围产期死亡率。采用逻辑回归来确定1940年至1944年出生的母亲与该时期之前或之后出生的母亲之间可能存在的队列效应。
占领期间挪威的恶劣状况增加了儿童死亡率。然而,围产期死亡率在该时期有所下降。同样,对于那些母亲本人在战争期间出生的婴儿的存活率,未观察到不利影响(优势比=1.00;95%置信区间=0.96,1.04)。
我们没有发现证据表明挪威的战时状况直接或通过对战争期间出生的女性的影响而损害围产期存活率。这些数据凸显了我们对社会状况影响围产期死亡率方式的了解是多么有限。