苯乙烯的代谢与毒性。
Metabolism and toxicity of styrene.
作者信息
Leibman K C
出版信息
Environ Health Perspect. 1975 Jun;11:115-9. doi: 10.1289/ehp.7511115.
Abstract
The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.
摘要
本文简要综述了苯乙烯在人和实验动物体内的吸收、血药浓度、分布、排泄及生物转化情况。苯乙烯的急性毒性似乎与其生物转化无关。关于长期接触苯乙烯后器官毒性的报道较少；然而，由于苯乙烯代谢的主要中间体是环氧化物，因此在其形成部位通过共价结合导致肝毒性似乎是有可能的。
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