苯乙烯的代谢与毒性。
Metabolism and toxicity of styrene.
作者信息
Leibman K C
出版信息
Environ Health Perspect. 1975 Jun;11:115-9. doi: 10.1289/ehp.7511115.
Abstract
The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.
摘要
本文简要综述了苯乙烯在人和实验动物体内的吸收、血药浓度、分布、排泄及生物转化情况。苯乙烯的急性毒性似乎与其生物转化无关。关于长期接触苯乙烯后器官毒性的报道较少；然而，由于苯乙烯代谢的主要中间体是环氧化物，因此在其形成部位通过共价结合导致肝毒性似乎是有可能的。
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本文引用的文献
1
CARCINOGENICITY OF EPOXIDES, LACTONES, AND PEROXY COMPOUNDS.环氧化物、内酯和过氧化物的致癌性。
J Natl Cancer Inst. 1963 Jul;31:41-55.
2
EXPERIMENTAL CARCINOGENICITY AND ACUTE TOXICITY OF REPRESENTATIVE EPOXIDES.代表性环氧化合物的实验致癌性和急性毒性
Am Ind Hyg Assoc J. 1963 Jul-Aug;24:305-25. doi: 10.1080/00028896309343226.
3
Organic peroxides, hydrogen peroxide, epoxides, and neoplasia.有机过氧化物、过氧化氢、环氧化物与肿瘤形成
Radiat Res. 1963;Suppl 3:193-211.
4
Studies in detoxication. 73. The metabolism of alkylbenzenes: phenylacetylene and phenylethylene (styrene).解毒研究。73. 烷基苯的代谢：苯乙炔和苯乙烯（乙烯基苯）。
Biochem J. 1958 Feb;68(2):199-204. doi: 10.1042/bj0680199.
5
Toxicological studies of certain alkylated benzenes and benzene; experiments on laboratory animals.某些烷基苯和苯的毒理学研究；对实验动物的实验
AMA Arch Ind Health. 1956 Oct;14(4):387-98.
6
The metabolism of styrene in the rat.
J Biol Chem. 1954 Dec;211(2):549-53.
7
The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat.苯乙基溴、苯乙烯和环氧苯乙烷在兔和大鼠体内的代谢
Biochem J. 1967 Sep;104(3):914-21. doi: 10.1042/bj1040914.
8
Oxidation of styrene in liver microsomes.苯乙烯在肝微粒体中的氧化作用。
Biochem Pharmacol. 1969 Feb;18(2):552-4. doi: 10.1016/0006-2952(69)90237-8.
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