Ayache D, Rocher P, Buzyn-Veil A, Roulleau P
Service d'ORL et Chirurgie Cervico-Faciale, Hôpital Necker Enfants-Malades, Paris.
Ann Otolaryngol Chir Cervicofac. 1993;110(8):478-81.
Kikuchi's disease is rare necrotic histiocytosis of the lymph nodes. Since the first description in Japan in 1972 by Kikuchi, several cases have been reported. The disease occurs most frequently in young women. Manifestations include enlargement of the cervical lymph nodes, sometimes with fever, and often associated with other non-specific clinical signs. Blood chemistry, including immunologic tests, are often normal but neutropenia and raised erythrocyte sedimentation rate have been reported. Diagnosis relies on the histological examination of lymph node biopsies. Generally the clinical course is favourable in 3-4 months. Secondary systemic lupus erythomatosus may develop and require regular follow-up. The aetiology of this rare disease is still unclear although certain observations would favour an immunological process. Very rare in France, we report a case of Kikuchi's disease in a pregnant woman and present a review of the literature.
菊池病是一种罕见的淋巴结坏死性组织细胞增多症。自1972年菊池在日本首次描述该病以来，已有多例病例报道。该病最常发生于年轻女性。临床表现包括颈部淋巴结肿大，有时伴有发热，且常伴有其他非特异性临床体征。血液检查，包括免疫检查，通常正常，但也有报道称存在中性粒细胞减少和红细胞沉降率升高的情况。诊断依赖于淋巴结活检的组织学检查。一般来说，临床病程在3至4个月内较为良好。可能会继发系统性红斑狼疮，需要定期随访。尽管某些观察结果支持免疫过程，但这种罕见疾病的病因仍不清楚。在法国极为罕见，我们报告了一例孕妇患菊池病的病例，并对相关文献进行了综述。
