五种喹诺酮类药物对肺炎衣原体的体外活性
In vitro activities of five quinolones against Chlamydia pneumoniae.
作者信息
Hammerschlag M R, Hyman C L, Roblin P M
机构信息
Department of Pediatrics, State University of New York, Brooklyn 11203.
出版信息
Antimicrob Agents Chemother. 1992 Mar;36(3):682-3. doi: 10.1128/AAC.36.3.682.
Abstract
The in vitro susceptibilities of 10 strains of Chlamydia pneumoniae were determined for five quinolones, including ciprofloxacin, ofloxacin, fleroxacin, temafloxacin, and sparfloxacin. Sparfloxacin was the most active compound tested, followed by ofloxacin and temafloxacin. Ciprofloxacin and fleroxacin were the least active. The use of HEp-2 cells for testing C. pneumoniae resulted in larger inclusions but essentially the same endpoints as were seen with use of HeLa 229 cells.
摘要
测定了10株肺炎衣原体对5种喹诺酮类药物的体外敏感性，这些药物包括环丙沙星、氧氟沙星、氟罗沙星、替马沙星和司帕沙星。司帕沙星是所测试的活性最强的化合物，其次是氧氟沙星和替马沙星。环丙沙星和氟罗沙星活性最低。使用HEp-2细胞检测肺炎衣原体导致包涵体更大，但与使用HeLa 229细胞时观察到的终点基本相同。
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