亚抑菌浓度亚胺培南对体外动态模型中铜绿假单胞菌的药效学作用
Pharmacodynamic effects of subinhibitory concentrations of imipenem on Pseudomonas aeruginosa in an in vitro dynamic model.
作者信息
Maggiolo F, Taras A, Frontespezi S, Legnani M C, Silanos M A, Pravettoni G, Suter F
机构信息
Department of Infectious Diseases, General Hospital, Busto Arsizio, Italy.
出版信息
Antimicrob Agents Chemother. 1994 Jun;38(6):1416-8. doi: 10.1128/AAC.38.6.1416.
Abstract
The postantibiotic effect (PAE), sub-MIC effect (SME), and postantibiotic sub-MIC effect (PASME) of imipenem on Pseudomonas aeruginosa were investigated with an in vitro dynamic model reproducing in vivo elimination kinetics of the antibiotic. The PASMEs were constantly longer than the corresponding SMEs, but differences between them were not statistically significant. Both PASMEs and SMEs were initially bactericidal and were significantly longer than PAEs. The mean values of both PASMEs and SMEs were over 12 h. SMEs appear to be more relevant for the bacterial growth kinetics than PAEs.
摘要
采用一种能再现抗生素体内消除动力学的体外动态模型，研究了亚胺培南对铜绿假单胞菌的抗生素后效应（PAE）、亚抑菌浓度效应（SME）和抗生素后亚抑菌浓度效应（PASME）。PASME持续时间始终长于相应的SME，但两者之间的差异无统计学意义。PASME和SME最初均具有杀菌作用，且显著长于PAE。PASME和SME的平均值均超过12小时。与PAE相比，SME似乎与细菌生长动力学更相关。
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本文引用的文献
1
Teicoplanin and its influence on Staphylococcus aureus ultrastructure.替考拉宁及其对金黄色葡萄球菌超微结构的影响。
J Chemother. 1991 Jan;3 Suppl 1:89-92.
2
Bactericidal activity of two different dosage regimens of imipenem in an in-vitro dynamic model.亚胺培南两种不同给药方案在体外动态模型中的杀菌活性。
J Antimicrob Chemother. 1993 Aug;32(2):295-300. doi: 10.1093/jac/32.2.295.
3
In vitro veritas? Antimicrobial susceptibility tests and their clinical relevance.“试管内为真？”抗菌药物敏感性试验及其临床相关性。
J Infect Dis. 1981 Oct;144(4):380-5. doi: 10.1093/infdis/144.4.380.
4
Intermittent or continuous therapy of experimental meningitis due to Streptococcus pneumoniae in rabbits: preliminary observations on the postantibiotic effect in vivo.兔肺炎链球菌所致实验性脑膜炎的间歇或持续治疗：体内抗生素后效应的初步观察
Rev Infect Dis. 1981 Jan-Feb;3(1):98-109. doi: 10.1093/clinids/3.1.98.
5
Dosage schedules of antimicrobial agents: a historical review.抗菌药物的给药方案：历史回顾。
Rev Infect Dis. 1981 Jan-Feb;3(1):4-11. doi: 10.1093/clinids/3.1.4.
6
Effect of subinhibitory concentrations of antibiotics on the adhesion of Streptococcus pyogenes to pharyngeal epithelial cells.亚抑菌浓度抗生素对化脓性链球菌黏附于咽上皮细胞的影响。
Antimicrob Agents Chemother. 1981 Nov;20(5):563-6. doi: 10.1128/AAC.20.5.563.
7
Current practices in antimicrobial dosing.抗菌药物给药的现行做法。
Rev Infect Dis. 1981 Jan-Feb;3(1):12-8. doi: 10.1093/clinids/3.1.12.
8
Postantibiotic effect of imipenem on Pseudomonas aeruginosa.亚胺培南对铜绿假单胞菌的抗生素后效应。
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9
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Eur J Clin Microbiol. 1983 Oct;2(5):414-25. doi: 10.1007/BF02013898.
10
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