Pitkänen O M, Hallman M, Andersson S M
Children's Hospital, University of Helsinki, Finland.
J Pediatr. 1990 May;116(5):760-4. doi: 10.1016/s0022-3476(05)82668-x.
Lipid peroxidation was measured in 19 very low birth weight infants with respiratory distress syndrome by quantitating ethane and pentane in expired air during the first 5 days postnatally. Despite high levels of inspiratory oxygen, the ethane and pentane output was low within the first 24 hours; thereafter it increased up to 100 and 30 fold, respectively. On days 1 to 3 there was no detectable correlation between lipid peroxidation and fractional inspiratory oxygen. However, on days 4 and 5, lipid peroxidation and fractional inspiratory oxygen showed a significant correlation. Maximal amounts of expired ethane and pentane were significantly higher for patients with a poor outcome (five deaths, six cases of bronchopulmonary dysplasia) than for those with good outcome (eight infants surviving intact) (p less than 0.01). The results imply a role for free oxygen radicals in the pathogenesis of life-threatening complications in the very low birth weight infant.
通过对19例患有呼吸窘迫综合征的极低出生体重儿出生后前5天呼出气体中的乙烷和戊烷进行定量分析，测定脂质过氧化情况。尽管吸入氧浓度较高，但在出生后的头24小时内，乙烷和戊烷的排出量较低；此后，它们分别增加了100倍和30倍。在第1至3天，脂质过氧化与吸入氧分数之间未发现明显相关性。然而，在第4天和第5天，脂质过氧化与吸入氧分数显示出显著相关性。预后不良的患者（5例死亡，6例支气管肺发育不良）呼出的乙烷和戊烷最大量显著高于预后良好的患者（8例完全存活的婴儿）（p<0.01）。结果表明，自由基在极低出生体重儿危及生命的并发症发病机制中起作用。
