Voloshchuk I N, Kogan E A, Sekamova S M, Shirinskaia O G
Arkh Patol. 1994 May-Jun;56(3):76-9.
The paper reports lethal intrauterine mycoplasmosis in a newborn girl. Her mother suffered from genital mycoplasmosis and had blood antibodies to Myc. Hominis and Ureapl. urealyticum. Most pronounced changes are found in the liver: hepatocyte degeneration and necrosis with PAS- and azur-positive granules in the cytoplasm of hepatocytes and macrophages, lymphohistiocytic infiltration of portal tracts and parenchyma, biliary duct proliferation, cholestases. The lungs: interstitial pneumonia with minimal alteration of the bronchial epithelium. The above spectrum of alterations suggests transplacental contamination. Ganglioneuroblastoma consisting of embryonal neuroblasts found in the adrenals is considered as an independent disease. The first child of this woman died 14-days old and had morphological signs of the intrauterine infection and pronounced liver dysplasia; possible oncogenicity of mycoplasma is discussed.
该论文报道了一名新生女婴的致死性宫内支原体感染。其母亲患有生殖器支原体感染，且血液中存在人型支原体和溶脲脲原体抗体。最显著的变化见于肝脏：肝细胞变性坏死，肝细胞和巨噬细胞胞质内有PAS和天青阳性颗粒，汇管区和实质内有淋巴细胞和组织细胞浸润，胆管增生，胆汁淤积。肺部：间质性肺炎，支气管上皮改变轻微。上述一系列改变提示经胎盘感染。肾上腺发现的由胚胎性神经母细胞组成的神经母细胞瘤被视为一种独立疾病。该女子的第一个孩子14日龄时死亡，有宫内感染的形态学表现及明显的肝脏发育不良；文中讨论了支原体可能的致癌性。
