Nuti M, Amaddeo D, Crovatto M, Ghionni A, Polato D, Lillini E, Pitzus E, Santini G F
Institute of Tropical and Infectious Diseases, University La Sapienza, Rome, Italy.
Am J Trop Med Hyg. 1993 Jan;48(1):20-5. doi: 10.4269/ajtmh.1993.48.20.
From 1987 to 1991, a seroepidemiologic survey for antibodies to hantaviruses, leptospira, rickettsiae, and Borrelia was conducted in selected Italian population groups. In the mountainous areas of northeastern Italy, the prevalence of antibody to hantaviruses, as detected by indirect immunofluorescent antibody (IFA) assay, was 7.1%, 4.8%, 4.3%, and 4% in 265 forestry workers, 82 rangers, 395 farmers, and 75 hunters, respectively. Among 299 Alpine soldiers, the prevalence was lower (0.7%). Of those with Hantaan antibody, the reactivity pattern using Hantaan, Puumala, and Fojnica viruses suggested a prevalence of antibody to Hantaan virus, with titers reaching levels of 128. The presence of leptospiral antibodies (by microagglutination test), which included the prevalence of antibodies to Leptospira icterohaemorrhagiae, L. bratislava, and L. saxkoening serotypes, was observed in 10-12% of the farmers and forestry workers in these Alpine mountain regions. Only a few sporadic clinical cases of leptospirosis have been reported from these regions. Antibodies to Borrelia burgdorferi (by IFA) were observed in 19% of the rangers and forestry workers, with lower values in farmers (10%) and hunters (8%). These data suggest the presence of a large number of asymptomatic infections with B. burgdorferi and the leptospires in the densely wooded areas of the Alpine Italian regions. Furthermore, the recent identification of a case of Hantaan acute nephropathy in a man living in the mountainous northeastern area of Italy confirms the presence of hantavirus in the Italian Alpine zones, especially those near the Slovenian border.
1987年至1991年期间，在意大利部分人群中开展了一项针对汉坦病毒、钩端螺旋体、立克次体和疏螺旋体抗体的血清流行病学调查。在意大利东北部山区，通过间接免疫荧光抗体（IFA）检测发现，265名林业工人、82名护林员、395名农民和75名猎人中，汉坦病毒抗体的流行率分别为7.1%、4.8%、4.3%和4%。在299名高山士兵中，流行率较低（0.7%）。在那些有汉滩病毒抗体的人中，使用汉滩病毒、普马拉病毒和福伊尼察病毒的反应模式表明汉滩病毒抗体流行，滴度达到128。在这些阿尔卑斯山区的农民和林业工人中，10% - 12%的人检测到钩端螺旋体抗体（通过微量凝集试验），其中包括出血性黄疸钩端螺旋体、布拉迪斯拉发钩端螺旋体和萨克森尼钩端螺旋体血清型的抗体。这些地区仅报告了少数散发性钩端螺旋体病临床病例。通过IFA检测发现，19%的护林员和林业工人中有伯氏疏螺旋体抗体，农民（10%）和猎人（8%）中的比例较低。这些数据表明，在意大利阿尔卑斯地区树木繁茂的地区存在大量无症状的伯氏疏螺旋体和钩端螺旋体感染。此外，最近在一名居住在意大利东北部山区的男子身上确诊了一例汉滩急性肾病，这证实了意大利阿尔卑斯地区，特别是靠近斯洛文尼亚边境的地区存在汉坦病毒。
