Nuti M, Amaddeo D, Autorino G L, Crovatto M, Crucil C, Ghionni A, Giommi M, Salvati F, Santini G F
Institute of Tropical and Infectious Diseases, University La Sapienza, Policlinico Umberto I, Rome, Italy.
Eur J Epidemiol. 1992 Jan;8(1):98-102. doi: 10.1007/BF03334979.
A study of hantaviral and leptospiral antibodies in selected population groups was performed. Among high risk subjects in the Rome area, Hantaan antibody was found in mammalogists (10%) and dialysis patients (6%), while none of the trappers, oarsmen, river policemen and firemen studied tested positive for antibodies to hantaviruses. In occupationally-exposed subjects (farmers, rangers, lumbermen, hunters) from rural and densely forested areas of northern Italian regions, the prevalence of Hantaan antibody ranged from 3.3% to 8.8%. In the positive cases the comparative antibody titration using different hantaviruses showed a predominance of Hantaan virus (titer 1:128) compared to Puumala virus (titer 1:32); no reactivity was observed with Seoul or Prospect Hill viruses. In Rome, leptospiral antibodies were found in trappers (21%) and oarsmen (5%) at a titer of 1:50 or more, with a predominance for the L. icterohaemorrhagiae serotype (85%). In the Alpine areas the leptospiral antibody prevalence was 12% and L. icterohaemorrhagiae and L. bratislava were the predominant serotypes. The presence of hantavirus infections, suspected after the first epidemiological survey conducted in central Italy, is now supported by the new data obtained in northern Italian regions. Furthermore, the recent observation of one case of Hemorrhagic Fever with Renal Syndrome (HFRS) in the Udine area, not far from the Yugoslavian border, strongly confirms the presence of one or more hantaviruses in Italy.
对特定人群组中的汉坦病毒和钩端螺旋体抗体进行了研究。在罗马地区的高危人群中，在哺乳动物学家（10%）和透析患者（6%）中发现了汉滩病毒抗体，而所研究的捕兽者、划桨手、内河警察和消防员中均未检测到汉坦病毒抗体呈阳性。在意大利北部农村和森林茂密地区的职业暴露人群（农民、护林员、伐木工、猎人）中，汉滩病毒抗体的患病率在3.3%至8.8%之间。在阳性病例中，使用不同汉坦病毒进行的比较抗体滴定显示，与普马拉病毒（滴度1:32）相比，汉滩病毒占优势（滴度1:128）；未观察到与汉城病毒或普罗斯佩克特山病毒的反应性。在罗马，捕兽者（21%）和划桨手（5%）中发现了钩端螺旋体抗体，滴度为1:50或更高，黄疸出血型钩端螺旋体血清型占优势（85%）。在阿尔卑斯地区，钩端螺旋体抗体患病率为12%，黄疸出血型钩端螺旋体和布拉迪斯拉发型钩端螺旋体是主要血清型。在意大利中部进行首次流行病学调查后怀疑存在的汉坦病毒感染，现在得到了意大利北部地区获得的新数据的支持。此外，最近在靠近南斯拉夫边境的乌迪内地区观察到一例肾综合征出血热（HFRS）病例，有力地证实了意大利存在一种或多种汉坦病毒。
