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Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

作者信息

Edwards C R, Benediktsson R, Lindsay R S, Seckl J R

机构信息

University of Edinburgh Department of Medicine, Western General Hospital, UK.

出版信息

Lancet. 1993 Feb 6;341(8841):355-7. doi: 10.1016/0140-6736(93)90148-a.

DOI:10.1016/0140-6736(93)90148-a
PMID:8094124
Abstract
摘要

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Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?胎盘糖皮质激素屏障功能障碍：胎儿环境与成人高血压之间的联系？
Lancet. 1993 Feb 6;341(8841):355-7. doi: 10.1016/0140-6736(93)90148-a.
2
Glucocorticoids and small babies.糖皮质激素与小婴儿
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Variation in placental type 2 11beta-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight.胎盘2型11β-羟类固醇脱氢酶活性的变化与出生体重或胎盘重量无关。
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Tissue-specific messenger ribonucleic acid expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action.大鼠胎盘内11β-羟类固醇脱氢酶1型和2型以及糖皮质激素受体的组织特异性信使核糖核酸表达表明糖皮质激素作用存在精细的局部调控。
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Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants.小早产儿的胎盘11β-羟基类固醇脱氢酶-2与胎儿皮质醇/可的松穿梭机制
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Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action.11β-羟基类固醇脱氢酶在胎盘中的双重功能：调节胎盘糖皮质激素的通过及局部类固醇作用
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11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-II) activity in human placenta: its relationship to placental weight and birth weight and its possible role in hypertension.人胎盘11β-羟基类固醇脱氢酶（11β-HSD-II）活性：其与胎盘重量和出生体重的关系及其在高血压中的可能作用。
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Variations in human placental 11 beta-dehydrogenase and 11-oxoreductase activities of 11 beta-hydroxysteroid dehydrogenase enzyme during pregnancy.孕期人胎盘11β-羟类固醇脱氢酶的11β-脱氢酶和11-氧化还原酶活性变化
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Glucocorticoids, 11beta-hydroxysteroid dehydrogenase, and fetal programming.糖皮质激素、11β-羟基类固醇脱氢酶与胎儿编程
Kidney Int. 2000 Apr;57(4):1412-7. doi: 10.1046/j.1523-1755.2000.00984.x.

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