Ding S F, Delhanty J D, Bowles L, Dooley J S, Wood C B, Habib N A
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Br J Cancer. 1993 Feb;67(2):244-6. doi: 10.1038/bjc.1993.47.
As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses.
目前，尚无关于纤维板层癌（FLC）染色体等位基因缺失的研究报道，纤维板层癌是肝细胞癌（HCC）一种独特的罕见变体。我们使用针对10条染色体的18个DNA探针来寻找FLC中等位基因缺失的证据，并将缺失模式与我们的HCC系列进行比较。其中两个探针，λMS32（1q42 - 43）和cMS621（5p）在一个肿瘤中显示等位基因缺失，而其他探针未显示缺失。FLC中等位基因缺失的频率远低于HCC，这可能与它们不同的预后相关。
