Ni J, Sato N, Fujii K, Yuge O
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Hiroshima University, Japan.
J Pharm Pharmacol. 1993 Jan;45(1):67-9. doi: 10.1111/j.2042-7158.1993.tb03682.x.
The excretion of sevoflurane metabolites in the urine collected every 12 h after sevoflurane anaesthesia was measured by ion exchange chromatography. A metabolite, which was converted on incubation with glucuronidase to hexafluoroisopropanol was detected in the urine. The maximum excretion was found in the first 12 h after anaesthesia, none was found in the last collection 3 days after anaesthesia. The excretion half-life for the metabolite was calculated to be 55 h. A significant increase in the urinary excretion of organic and inorganic fluoride was also observed during the first 12 h after anaesthesia. The cumulative organic and inorganic fluoride excretion in the 3 days after sevoflurane anaesthesia was 1588 and 856 mumol, respectively (ratio = 1.85). The excreted half-lives for organic and inorganic fluoride were calculated to be 4028 and 2069 min, respectively. Our study showed that a hexafluoroisopropanol glucuronide is excreted in the urine, and the major part of urinary metabolites of sevoflurane, organic and inorganic fluoride, are excreted within 2 days of sevoflurane inhalation in man.
采用离子交换色谱法测定七氟醚麻醉后每12小时收集的尿液中七氟醚代谢物的排泄情况。在尿液中检测到一种代谢物，该代谢物与葡萄糖醛酸酶孵育后可转化为六氟异丙醇。麻醉后最初12小时内排泄量最大，麻醉后3天的最后一次收集样本中未发现代谢物。该代谢物的排泄半衰期经计算为55小时。麻醉后最初12小时内还观察到有机氟和无机氟的尿排泄量显著增加。七氟醚麻醉后3天内有机氟和无机氟的累积排泄量分别为1588和856 μmol（比率 = 1.85）。有机氟和无机氟的排泄半衰期经计算分别为4028和2069分钟。我们的研究表明，六氟异丙醇葡萄糖醛酸苷经尿液排泄，七氟醚的尿代谢物、有机氟和无机氟的主要部分在人体吸入七氟醚后2天内排泄。
