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Six groups of 45-day-old, 23.0 +/- 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LD50 was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.

将六组45日龄、体重23.0±1.7克的雌性Balb/c小鼠腹腔注射63、252、440、630、2520或6300国际单位的维生素D，持续6天。第七组注射生理盐水。每组由30只动物组成。
所有接种2520和6300国际单位剂量的动物以及70%接种630国际单位维生素D的小鼠在首次注射维生素后21天死亡。半数致死量为630国际单位。
将存活的小鼠分为两组，腹腔注射5000个克氏锥虫Y株或CL株的锥鞭毛体。
根据感染后第73天的存活指数，维生素D分别对接种63或430国际单位Y株或CL株的小鼠具有统计学上显著的保护作用（P<0.01）。
组织病理学检查显示，接受较高剂量维生素D的动物炎症反应以及细胞和组织寄生程度较轻。
得出结论，维生素D过量对Balb/c小鼠克氏锥虫CL株和Y株感染具有保护作用。

Six groups of 45-day-old, 23.0 +/- 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LD50 was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.

将六组45日龄、体重23.0±1.7克的雌性Balb/c小鼠腹腔注射63、252、440、630、2520或6300国际单位的维生素D，持续6天。第七组注射生理盐水。每组由30只动物组成。
所有接种2520和6300国际单位剂量的动物以及70%接种630国际单位维生素D的小鼠在首次注射维生素后21天死亡。半数致死量为630国际单位。
将存活的小鼠分为两组，腹腔注射5000个克氏锥虫Y株或CL株的锥鞭毛体。
根据感染后第73天的存活指数，维生素D分别对接种63或430国际单位Y株或CL株的小鼠具有统计学上显著的保护作用（P<0.01）。
组织病理学检查显示，接受较高剂量维生素D的动物炎症反应以及细胞和组织寄生程度较轻。
得出结论，维生素D过量对Balb/c小鼠克氏锥虫CL株和Y株感染具有保护作用。

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