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津巴布韦蛇毒中毒的回顾性研究。

A retrospective study of poisoning due to snake venom in Zimbabwe.

作者信息

Kasilo O M, Nhachi C F

机构信息

Drug and Toxicology Information Service (DaTIS), Department of Pharmacy, University of Zimbabwe Medical School, Avondale, Harare.

出版信息

Hum Exp Toxicol. 1993 Jan;12(1):15-8. doi: 10.1177/096032719301200103.

DOI:10.1177/096032719301200103
PMID:8094964
Abstract
  1. Hospital records at the six major referral hospitals in urban Zimbabwe were reviewed for the years 1980-1989 in order to determine the types of snake, incidence, morbidity and mortality associated with snake venom poisoning. 2. A total of 1087 cases of animal toxin poisoning were retrieved retrospectively, 91.5% (995) of which were due to snake venom poisoning. Of the 995 cases, 50.9% (506) were females and 49.1% (489) males. The majority of patients were aged from 21 to 30 years (22%), followed by the 6-15 (16%) and the 16-20 year age groups (11%), respectively. 3. The mean period of hospitalization of a snake venom-poisoned patient was found to be 2 d (the range was 1 d-9 weeks). The mean total cost of keeping (excluding treatment) a poisoned patient during that period was calculated at Zimbabwean dollars (Zw$) 450.00 (US$ 225.00) per day. The total number of hospitalization days was 344 and the cost of keeping the patients in hospital was therefore Zw$ 154,800 (i.e. US$ 77,400). 4. The first-line treatment most used was a combination of antibiotics (44.6%), alone or with an antivenom tropical snake polyvalent (ATT) (21.2%), and analgesics (19.9%). 5. Mortality was recorded at 1.8% (18 patients) and the few records of the types of snakes associated with envenomation in order of frequency were the cobra, adders (puff and night), mamba and boomslang. The prevention and prompt treatment of snake envenomation is of priority in the reduction of incidence of poisoning.
摘要
  1. 为了确定与蛇毒中毒相关的蛇的种类、发病率、发病率和死亡率,对津巴布韦城市六家主要转诊医院1980 - 1989年的医院记录进行了审查。2. 共回顾性检索到1087例动物毒素中毒病例,其中91.5%(995例)是由蛇毒中毒引起的。在这995例病例中,50.9%(506例)为女性,49.1%(489例)为男性。大多数患者年龄在21至30岁之间(22%),其次是6至15岁(16%)和16至20岁年龄组(11%)。3. 发现蛇毒中毒患者的平均住院时间为2天(范围为1天至9周)。在此期间,一名中毒患者的平均总饲养成本(不包括治疗费用)计算为每天450.00津巴布韦元(225.00美元)。住院总天数为344天,因此患者住院的费用为154,800津巴布韦元(即77,400美元)。4. 最常用的一线治疗方法是抗生素联合使用(44.6%),单独使用或与抗蛇毒热带多价血清(ATT)联合使用(21.2%),以及镇痛药(19.9%)。5. 记录的死亡率为1.8%(18例患者),按频率顺序记录的与中毒相关的蛇的种类的少数记录是眼镜蛇、蝰蛇(鼓腹和夜蝰)、曼巴蛇和树眼镜蛇。预防和及时治疗蛇毒中毒是降低中毒发病率的优先事项。

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