McMillan T M, Freemont A J, Herxheimer A, Denton J, Taylor A P, Pazianas M, Cummin A R, Eastwood J B
Department of Clinical Neuropsychology, Atkinson Morley's Hospital, Copse Hill, London, UK.
Hum Exp Toxicol. 1993 Jan;12(1):37-42. doi: 10.1177/096032719301200108.
The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and measurements of anxiety and depression. Serial bone biopsies in two individuals showed that the aluminium which was present 6 and 7 months after the accident had disappeared by 19 months. In the eight individuals biopsied 12-17 months after the accident the bone showed no stainable aluminium. Thus, aluminium deposited in the bone of normal individuals can disappear within 18 months. After an accident such as that at Camelford important evidence of toxicity is likely to be missed if an investigation is delayed. The abnormal neuropsychological findings indicate cognitive impairment, but whether this was caused by an acute episode of brain damage, or other causes such as the psychological effects of stress resulting from the accident, is uncertain.
对康沃尔郡卡梅尔福德的水意外被硫酸铝污染后8至26个月内的10名个体进行的系列认知评估显示，有持续证据表明信息处理和记忆受损。这些损伤与焦虑和抑郁的测量之间没有明显关系。对两名个体进行的系列骨活检显示，事故发生6个月和7个月时存在的铝在19个月时已消失。在事故发生12至17个月后接受活检的8名个体中，骨骼未显示可染色的铝。因此，沉积在正常个体骨骼中的铝可在18个月内消失。在像卡梅尔福德这样的事故之后，如果调查延迟，很可能会错过重要的毒性证据。异常的神经心理学发现表明存在认知障碍，但这是由急性脑损伤发作引起的，还是由其他原因（如事故导致的压力的心理影响）引起的，尚不确定。
