Ramsden R T, Bulman C H, Lorigan B P
J Laryngol Otol. 1975 Sep;89(9):941-55. doi: 10.1017/s0022215100081226.
A series of twenty-nine cases of osteoradionecrosis of the temporal bone is described. Two patterns occur: a localized involvement of the tympanic plate which resolves after the spontaneous separation of a sequestrum of bone, and a more diffuse necrosis of the temporal bone with a high risk of involvement of adjacent structures, in particular the brain, labyrinth and facial nerve and to a lesser extent the temporomandibular joint and the parotid gland. Localized osteonecrosis occurs more commonly when the temporal bone is in the periphery of an irradiated field whereas irradiation aimed primarily at the temporal bone is more likely to be followed by diffuse disease. The use of megavoltage irradiation has not led to the disappearance of the complication which may occur as much as twenty years after the completion of the course of radiotherapy.
本文描述了29例颞骨放射性骨坏死病例。有两种类型:一种是鼓膜板局限性受累,在死骨自发分离后可自行缓解;另一种是颞骨更广泛的坏死,累及相邻结构的风险较高,尤其是脑、迷路和面神经,颞下颌关节和腮腺受累程度较轻。局限性骨坏死更常见于颞骨位于照射野周边时,而主要针对颞骨的照射更易引发广泛性病变。兆伏级放疗的应用并未使该并发症消失,其可能在放疗疗程结束后长达20年出现。