Fetter A, Partisani M, Koenig H, Kremer M, Lang J M
Centre d'Information et de Soins de I'immunodéficience Humaine, Hôpitaux Universitaires de Strasbourg, France.
J Oral Pathol Med. 1993 Feb;22(2):57-9. doi: 10.1111/j.1600-0714.1993.tb00043.x.
Many studies have focused on the epidemiology and pathogenesis of oral candidiasis in HIV infection. Little is known on the incidence and predisposing factors of asymptomatic oral candida carriage in this setting, obviously an important issue in view of prophylaxis. To address this question, 261 consecutive HIV-infected individuals without clinical evidence of candidiasis were investigated. C. albicans was isolated from cultured oral cavity swabs of 63 subjects (24%). Colonization was significantly more frequent in IV drug users, CDC groups IV, and in subjects with lymphocytopenia, CD4+ cell depletion, or elevated beta-2 microglobulin. These data further suggest that oral candidiasis occurs in HIV infection as a result of C. albicans overgrowth and raise the question of primary antifungal prophylaxis in subjects with low CD4 counts and asymptomatic oral Candida carriage.
许多研究都聚焦于HIV感染中口腔念珠菌病的流行病学和发病机制。对于这种情况下无症状口腔念珠菌携带的发生率和诱发因素知之甚少，鉴于预防的原因，这显然是一个重要问题。为了解决这个问题，对261名连续的无念珠菌病临床证据的HIV感染者进行了调查。从63名受试者（24%）的口腔培养拭子中分离出白色念珠菌。在静脉吸毒者、疾病控制中心IV组以及淋巴细胞减少、CD4+细胞耗竭或β2微球蛋白升高的受试者中，定植明显更为频繁。这些数据进一步表明，HIV感染中口腔念珠菌病是白色念珠菌过度生长的结果，并提出了对CD4计数低且有无症状口腔念珠菌携带的受试者进行原发性抗真菌预防的问题。
