莱姆病中的分子模拟：针对伯氏疏螺旋体鞭毛蛋白的单克隆抗体H9724可特异性检测伴侣蛋白HSP60。
Molecular mimicry in Lyme disease: monoclonal antibody H9724 to B. burgdorferi flagellin specifically detects chaperonin-HSP60.
作者信息
Dai Z, Lackland H, Stein S, Li Q, Radziewicz R, Williams S, Sigal L H
机构信息
Center for Advanced Biotechnology and Medicine, Piscataway, NJ.
出版信息
Biochim Biophys Acta. 1993 Mar 24;1181(1):97-100. doi: 10.1016/0925-4439(93)90096-j.
PMID:8096152
Abstract
A monoclonal antibody (H9724), specific for the 41-kDa flagellar protein of the Lyme disease pathogen Borrelia burgdorferi, cross-reacts with human axons and detects one major protein in human neuroblastoma cell extracts. The homologous cross-reacting protein has now been isolated from calf adrenal and identified as chaperonin-HSP60 by N-terminal sequencing.
摘要
一种单克隆抗体（H9724），对莱姆病病原体伯氏疏螺旋体的41-kDa鞭毛蛋白具有特异性，与人轴突发生交叉反应，并在人神经母细胞瘤细胞提取物中检测到一种主要蛋白质。现在已经从小牛肾上腺中分离出同源交叉反应蛋白，并通过N端测序鉴定为伴侣蛋白-HSP60。
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