Möller H J
Psychiatrische Universitätsklinik, Bonn, Germany.
Eur Neuropsychopharmacol. 1993 Mar;3(1):1-11. doi: 10.1016/0924-977x(93)90289-x.
The development and evaluation of the use of neuroleptics for negative symptoms of schizophrenia is becoming more and more of interest. However, severe methodological problems can lead to wrong conclusions in this field. The differentiation between primary and secondary negative symptoms and the interrelationship between negative symptoms, depression and akinesia have to be carefully considered. Many studies in this field are not conclusive because of such methodological pitfalls. After a careful review of published studies in this field no final conclusions can be drawn as to whether neuroleptics in general are effective in primary minus symptoms or whether certain neuroleptics are superior to others. Negative symptoms accompanying productive symptoms do improve with the neuroleptic treatment of the productive symptoms.
使用抗精神病药物治疗精神分裂症阴性症状的研究与评估越来越受到关注。然而，严重的方法学问题可能导致该领域得出错误结论。必须仔细考虑原发性和继发性阴性症状之间的区别以及阴性症状、抑郁和运动不能之间的相互关系。由于这些方法学上的缺陷，该领域的许多研究尚无定论。在仔细回顾该领域已发表的研究后，关于抗精神病药物总体上对原发性减状症状是否有效，或者某些抗精神病药物是否优于其他药物，无法得出最终结论。伴有阳性症状的阴性症状会随着对阳性症状的抗精神病药物治疗而改善。
