向黄鼠视交叉上核注射阿片受体拮抗剂对其冬眠的影响。

Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.

Yu L C, Cai Y P

Department of Physiology, Peking University, Beijing, P.R. China.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Feb;104(2):249-52.

Abstract

Drugs were administered to a suprachiasmatic nucleus through a chronically implanted cannula at the second day of a torpor bout of hibernating ground squirrels. After naltrexone injection, the body temperature of the hibernating animals increased and they aroused from hibernation within 20 hr after the injection. 2. Further experiments show that intra-suprachiasmatic nucleus perfusion of 1 nmol of ICI 174864 or nor-BNI, not beta-FNA, were able to increase the body temperature of hibernating ground squirrels and aroused them from hibernation within 20 hr after the injection.

摘要

在冬眠地松鼠进入蛰伏期的第二天，通过长期植入的套管将药物注入视交叉上核。注射纳曲酮后，冬眠动物的体温升高，并在注射后20小时内从冬眠中苏醒。2. 进一步的实验表明，视交叉上核内灌注1纳摩尔的ICI 174864或去甲BNI（而非β-FNA）能够使冬眠地松鼠的体温升高，并在注射后20小时内使其从冬眠中苏醒。