Kahn R A, Syring R L
Transfusion. 1975 Jul-Aug;15(4):363-7. doi: 10.1046/j.1537-2995.1975.15476034560.x.
Bacteria were intentionally introduced into units of whole blood. Platelet concentrates (PC) which were made from these units were stored at either room temperature (22 C) or at 4 C. In order to isolate small numbers of bacteria from a PC (i.e., 1 to 10 organisms per ml), substantial contamination (42 to 125 organisms per ml) of the whole blood was required. If the PC were stored at room temperature, all organisms except Pseudomonas aeruginosa, which was apparently killed, grew out of control within 48 hours. Storage of PC at 4 C resulted in the general maintenance of bacterial numbers. Since gross contamination of PC has only occasionally been reported, we conclude that past reports of modest contamination of platelet concentrates are primarily sampling artifacts.
细菌被有意引入全血单位中。由这些全血单位制备的血小板浓缩物（PC）分别储存在室温（22℃）或4℃下。为了从PC中分离出少量细菌（即每毫升1至10个生物体），全血需要大量污染（每毫升42至125个生物体）。如果PC储存在室温下，除明显被杀灭的铜绿假单胞菌外，所有生物体在48小时内均失控生长。将PC储存在4℃导致细菌数量总体维持不变。由于仅偶尔报告过PC的严重污染，我们得出结论，过去关于血小板浓缩物轻度污染的报告主要是抽样假象。
