Jurkovic D, Jauniaux E, Campbell S, Pandya P, Cardy D L, Nicolaides K H
Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London.
Lancet. 1993 Jun 26;341(8861):1623-4. doi: 10.1016/0140-6736(93)90761-5.
Chorionic villus sampling and amniocentesis have disadvantages. In 100 women undergoing termination of pregnancy, coelomic fluid was successfully aspirated in 96% of cases at 6-10 weeks' gestation, 42% at 11, and 10% at 12 weeks. Cytogenetic analysis always failed with coelomic fluid, but fetal sexing was always successful with fluorescence in-situ hybridisation and polymerase chain reaction, and the results agreed with those obtained from chorionic villi and amniotic fluid in all cases. Coelocentesis may be suitable for prenatal diagnosis in the first trimester.
绒毛取样和羊膜穿刺术都有缺点。在100名接受终止妊娠的女性中，在妊娠6至10周时，96%的病例成功抽取了体腔液；11周时为42%；12周时为10%。体腔液的细胞遗传学分析总是失败，但通过荧光原位杂交和聚合酶链反应进行胎儿性别鉴定总是成功的，并且所有病例的结果与从绒毛膜绒毛和羊水获得的结果一致。体腔穿刺术可能适用于孕早期的产前诊断。
