Ferrarini M, Bargellesi A, Corte G, Viale G, Pernis B
Ann N Y Acad Sci. 1975 Jun 30;254:243-53. doi: 10.1111/j.1749-6632.1975.tb29174.x.
Immunofluorescent and "in vitro" biosynthetic techniques have been used to study the connections between the maturation process of human lymphocytes that leads to the appearance of actively secreting cells and a possible switchover from IgD to IgM production, both in homogeneous CLL cell populations and in heterogeneous cell suspensions from tonsils. The results obtained are compatible with the hypothesis that the switchover from IgD to IgM productions can be a clonal maturation phenomenon.
免疫荧光和“体外”生物合成技术已被用于研究人类淋巴细胞成熟过程之间的联系，该过程导致活跃分泌细胞的出现以及在均一的慢性淋巴细胞白血病（CLL）细胞群体和来自扁桃体的异质细胞悬液中从IgD产生到IgM产生的可能转换。所获得的结果与从IgD产生到IgM产生的转换可能是一种克隆成熟现象的假设相符。
