Gordon J, Smith J L, Newell D, Chisholm M, Corte G, Warley A, Richardson N
Clin Exp Immunol. 1977 Oct;30(1):70-6.
A case of chronic lymphocytic leukaemia (CLL) with diffuse intracellular IgDkappa is reported. No serum paraprotein or urinary Bence-Jones protein were detected. No surface immunoglobulin was found on the neoplastic lymphocytes, but the cells had receptors for Fcgamma and the C3 component of complement consistent with other cases of CLL. Biosynthetic studies confirmed that the cells synthesized IgDkappa but there was no evidence for secretion of IgD into the culture medium. The cells did not produce Ig of any other class. The intracellular IgD occurred predominantly as deltakappa units with no covalent links between the chains. These findings are discussed.
报告了一例伴有弥漫性细胞内IgDκ的慢性淋巴细胞白血病（CLL）。未检测到血清副蛋白或尿本-周蛋白。在肿瘤淋巴细胞上未发现表面免疫球蛋白，但这些细胞具有Fcγ受体和补体C3成分受体，与其他CLL病例一致。生物合成研究证实这些细胞合成了IgDκ，但没有证据表明IgD分泌到培养基中。这些细胞不产生任何其他类别的Ig。细胞内IgD主要以δκ单位形式存在，链之间没有共价连接。对这些发现进行了讨论。
