人类淋巴细胞表面免疫球蛋白M、免疫球蛋白D和游离轻链的出现情况。
Occurrence of surface IgM, IgD, and free light chains of human lymphocytes.
作者信息
Fu S M, Winchester R J, Kunkel H G
出版信息
J Exp Med. 1974 Feb 1;139(2):451-6. doi: 10.1084/jem.139.2.451.
Abstract
An analysis was made of the immunoglobulin surface markers of the cells of patients with chronic lymphatic leukemia (CLL) in view of previous evidence of their monoclonal B-cell character. The simultaneous presence of IgM and IgD on the surface of the majority of lymphocytes was demonstrated by both immunofluorescence and hemagglutination inhibition in most cases. However, cases were observed with surface IgM without IgD as well as cases with IgD without IgM. IgG and IgA were absent. Studies of the light chains indicated only a single class in a given case. In addition to bound light chains, free light chains were readily demonstrated in most cases through the use of antisera specific for "free chain" determinants. It thus appeared that there are three major types of surface Ig on CLL lymphocytes, IgM, IgD, and free light chains.
摘要
鉴于慢性淋巴细胞白血病（CLL）患者细胞的单克隆B细胞特性已有先前证据，对其免疫球蛋白表面标志物进行了分析。在大多数情况下，通过免疫荧光和血凝抑制法均证实，大多数淋巴细胞表面同时存在IgM和IgD。然而，也观察到了表面仅有IgM而无IgD的病例以及仅有IgD而无IgM的病例。未检测到IgG和IgA。轻链研究表明，在特定病例中仅有一种类型。除了结合的轻链外，在大多数情况下，通过使用针对“游离链”决定簇的抗血清，很容易检测到游离轻链。因此，CLL淋巴细胞表面似乎存在三种主要类型的表面免疫球蛋白，即IgM、IgD和游离轻链。
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