MacArthur R D, Levine S D, Birk T J
Department of Medicine, Toledo 43699.
Med Sci Sports Exerc. 1993 Jun;25(6):684-8.
We attempted to measure cardiopulmonary effects, CD4 counts, and perceived sense of well-being in 25 individuals moderately to severely immunocompromised from HIV infection (mean entry CD4 count = 144.microliters-1) before and after a 24-wk program of exercise training. Only six subjects completed the 24-wk program. All six showed evidence of a training effect. Statistically significant improvements were seen in maximal oxygen consumption (VO2max), oxygen pulse, and minute ventilation. Submaximal exercise performance improved significantly by 12 wk in the 10 individuals available for testing: decreases were seen in heart rate, rate pressure product, and rate of perceived exertion. White blood cell counts and T-lymphocyte subsets were stable at 12 and 24 wk in the subjects available for testing. High depression/anxiety scores on a mental health inventory (General Health Questionnaire) correlated with low CD4 counts. Scores did not correlate with compliance with the exercise program. There was a trend (P < 0.10) for scores to improve over time among those individuals who attended > or = 80% of scheduled exercise sessions. We conclude that exercise training is feasible and beneficial for some HIV-infected individuals.
我们试图在25名因感染HIV而处于中度至重度免疫受损状态的个体（入组时CD4细胞计数平均值 = 144/微升）中，测量心肺功能、CD4细胞计数以及主观幸福感，测量时间分别为24周运动训练计划前后。只有6名受试者完成了24周的训练计划。这6名受试者均显示出训练效果。最大摄氧量（VO2max）、氧脉搏和每分通气量均有统计学意义的显著改善。在可进行测试的10名受试者中，次最大运动能力在12周时显著提高：心率、心率血压乘积和主观用力程度均有所下降。在可进行测试的受试者中，白细胞计数和T淋巴细胞亚群在12周和24周时保持稳定。心理健康量表（一般健康问卷）上的高抑郁/焦虑评分与低CD4细胞计数相关。评分与运动计划的依从性无关。在参加了≥80%预定锻炼课程的个体中，评分有随时间改善的趋势（P < 0.10）。我们得出结论，运动训练对一些感染HIV的个体是可行且有益的。
