Hand Gregory A, Phillips Kenneth D, Dudgeon Wesley D, William Lyerly G, Larry Durstine J, Burgess Stephanie E
Arnold School of Public Health, University of South Carolina, Columbia, USA.
AIDS Care. 2008 Oct;20(9):1066-74. doi: 10.1080/09540120701796900.
HIV infection and HIV drug therapies result in physical and psychological challenges to those living with HIV. These conditions contribute to decreased functional aerobic capacity (FAC). The aim of this study was to determine the effects of a combined moderate-intensity aerobic and resistance exercise intervention on the FAC of HIV-infected individuals. Forty HIV-infected individuals were randomized to an exercise group (EX) who completed six weeks of moderate-intensity exercise training, or to a control group (CON) that did not receive the exercise intervention. Twice weekly, the EX group completed 30 minutes of moderate-intensity aerobic training followed by moderate-intensity resistance training. Prior to, and following, the intervention the FAC for each subject was determined by graded exercise treadmill stress test (GXT). At baseline testing, the mean FAC as determined by treadmill time-based estimation of maximal oxygen consumption was 25% below age-predicted values, a level of reduction indicating the presence of functional aerobic impairment (FAI). Following the intervention, the EX had a significant increase in time to fatigue and estimated VO(2) max (p<.001). Further, FAI was eliminated (1% above age predicted values) during the exercise training. The EX group also experienced decreased heart rates during Stages 1 (p=.02), 2 (p=.01), 4 (p=.05) and 6 (p=.02) of the GXT. The CON had no significant changes during the intervention period. These data indicate that six weeks of combined moderate-intensity aerobic and resistance training can improve FAC and eliminate FAI in those with HIV. Results suggest that the functional limitations common in HIV-infected individuals are due in part to detraining that is reversible through moderate exercise adherence.
艾滋病毒感染及抗逆转录病毒疗法给艾滋病毒感染者带来了生理和心理挑战。这些情况导致功能性有氧能力（FAC）下降。本研究旨在确定中等强度有氧和抗阻运动相结合的干预措施对艾滋病毒感染者功能性有氧能力的影响。40名艾滋病毒感染者被随机分为运动组（EX）和对照组（CON），运动组完成为期六周的中等强度运动训练，对照组不接受运动干预。运动组每周两次，先进行30分钟中等强度有氧训练，然后进行中等强度抗阻训练。在干预前后，通过运动平板分级负荷试验（GXT）测定每位受试者的功能性有氧能力。在基线测试时，通过基于跑步机时间估算的最大耗氧量得出的平均功能性有氧能力比年龄预测值低25%，这一降低水平表明存在功能性有氧损伤（FAI）。干预后，运动组的疲劳时间和估计的最大摄氧量（VO₂max）显著增加（p<0.001）。此外，在运动训练期间功能性有氧损伤被消除（比年龄预测值高1%）。运动组在运动平板分级负荷试验的第1阶段（p = 0.02）、第2阶段（p = 0.01）、第4阶段（p = 0.05）和第6阶段（p = 0.02）心率也有所下降。对照组在干预期内无显著变化。这些数据表明，六周的中等强度有氧和抗阻训练相结合可改善艾滋病毒感染者的功能性有氧能力并消除功能性有氧损伤。结果表明，艾滋病毒感染者常见的功能限制部分归因于废用性训练不足，而通过坚持适度运动这种情况是可逆的。
