适度耐力训练（马拉松训练）——对HIV感染患者免疫和代谢参数的影响：42公里科隆项目

Moderate endurance training (marathon-training) - effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project.

作者信息

Schlabe Stefan, Vogel Martin, Boesecke Christoph, Schwarze-Zander Carolynne, Rockstroh Jürgen K, Körner Christian, Brixius Klara, Wasmuth Jan-Christian

机构信息

Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

出版信息

BMC Infect Dis. 2017 Aug 8;17(1):550. doi: 10.1186/s12879-017-2651-y.

DOI:10.1186/s12879-017-2651-y

PMID:28789630

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5549338/

Abstract

BACKGROUND

Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce.

METHODS

21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to immunology, quality of life and metabolism were measured at 4 time points (at baseline 1 year before the marathon run, 3 and 6 months after beginning of training, and immediately before marathon).

RESULTS

13 out of 21 participants completed the marathon (12 male, 1 female; median age 42 years [27-50]; CD4 = 620/μl [146-1268]; 11 were on ART since 3.5 years [1-7]). 8 participants ceased training early. All reasons for stopping (besides one pre-existing metatarsal fracture) were not regarded as training-related (e.g. time limitation n = 3; newly diagnosed anal cancer n = 1; personal reasons/unknown n = 3). We observed a significant increase in absolute CD4-T-cells (620/μl [146-1268] vs. 745 [207-1647]; p = 0.001) with simultaneous decrease of CD4-T-cell apoptosis (53% [47-64] vs. 32% [14-42]); p < 0.01). No effects on viral load independent of ART occurred. Systolic blood pressure and cholesterol improved significantly, although moderate and normal at baseline (cholesterol 185 mg/dl [98-250] vs. 167 [106-222], p = 0.02; RRsys 125 mmHg [100-145] vs. 120 [100-140], p = 0.01). Blood count, liver enzymes, creatinine and CK remained unchanged.

CONCLUSIONS

The results of this pilot study indicated improved metabolic and immunologic parameters in HIV-infected patients undergoing moderate endurance training. Although training effects or ART cannot be ultimately separated as underlying mechanisms, we conclude that marathon training is safe for HIV-infected patients and potentially improves general health.

TRIAL REGISTRATION

DRKS00011592 (retrospectively registered on February 9th 2017).

摘要

背景

艾滋病病毒（HIV）治疗方案的改进使许多HIV感染者能够定期进行体育活动。然而，关于运动对HIV患者影响的数据却很稀少。

方法

对21名准备参加马拉松赛跑的HIV感染者进行前瞻性监测。在4个时间点（马拉松赛跑前1年的基线期、训练开始后3个月和6个月以及马拉松赛跑前即刻）测量了免疫、生活质量和代谢方面的多个参数。

结果

21名参与者中有13人完成了马拉松（12名男性，1名女性；中位年龄42岁[27 - 50岁]；CD4细胞计数 = 620/μl [146 - 1268]；11人接受抗逆转录病毒治疗（ART）已3.5年[1 - 7年]）。8名参与者提前停止训练。所有停止训练的原因（除了1例既往存在的跖骨骨折）均不被认为与训练相关（例如时间限制n = 3；新诊断的肛管癌n = 1；个人原因/不明n = 3）。我们观察到绝对CD4 - T细胞显著增加（620/μl [146 - 1268]对745 [207 - 1647]；p = 0.001），同时CD4 - T细胞凋亡减少（53% [47 - 64]对32% [14 - 42]；p < 0.01）。对独立于ART的病毒载量没有影响。收缩压和胆固醇显著改善，尽管基线时处于中度和正常水平（胆固醇185mg/dl [98 - 250]对167 [106 - 222]，p = 0.02；收缩压RRsys 125mmHg [100 - 145]对120 [100 - 140]，p = 0.01）。血细胞计数、肝酶、肌酐和肌酸激酶保持不变。