吡哌酸及相关化合物对R质粒接合转移的抑制作用。
Inhibition of conjugal transfer of R plasmids by pipemidic acid and related compounds.
作者信息
Nakamura S, Inoue S, Shimizu M, Iyobe S, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1976 Nov;10(5):779-85. doi: 10.1128/AAC.10.5.779.
Abstract
It was found that pipemidic acid and related compounds have the common property of inhibiting the conjugal transfer of R plasmids carried by Escherichia coli and Pseudomonas aeruginosa. This inhibition was not due to bactericidal activity of the compounds against donors, recipients, or R(+) transconjugants. However, it was correlated inversely with their minimal inhibitory concentrations, depending especially upon sensitivity of donors to the compounds. The inhibition was generally observed in mating systems using various combinations of 14 R plasmids and 9 bacterial strains. The pretreatment of a donor or a recipient strain with pipemidic acid showed only a small inhibitory effect on the transfer of an R plasmid, whereas the presence of the compound during an active mating caused a marked inhibitory effect.
摘要
研究发现，吡哌酸及相关化合物具有抑制大肠杆菌和铜绿假单胞菌携带的R质粒接合转移的共同特性。这种抑制作用并非由于这些化合物对供体菌、受体菌或R（+）转接合子具有杀菌活性。然而，它与这些化合物的最低抑菌浓度呈负相关，尤其取决于供体菌对这些化合物的敏感性。在使用14种R质粒和9种菌株的各种组合的交配系统中普遍观察到这种抑制作用。用吡哌酸对供体菌或受体菌进行预处理对R质粒的转移仅显示出很小的抑制作用，而在活跃交配过程中存在该化合物则会产生显著的抑制作用。
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