Dollfus S, Petit M, Menard J F
University of Rouen, Department of Psychiatry, CHS du Rouvray, Sotteville Les Rouen, France.
J Affect Disord. 1993 May;28(1):61-9. doi: 10.1016/0165-0327(93)90078-x.
The aim of this study was to investigate the relationship between depressive and positive symptoms, two positive symptom using scales (PANSS and SAPS) in samples defined by three schizophrenic diagnostic systems (DSMIII-R, ICD9 and Langfeldt) at difference phases of the illness and in taking into account the negative and extrapyramidal symptoms and the doses of neuroleptics. With both scales, correlations between depressive and positive symptoms were significantly negative in two diagnostic subgroups (DSMIII-R and Langfeldt) in the acute phase. These correlations were also significant when negative symptoms, subjective extrapyramidal signs and the doses of neuroleptics were partialled out. Only the extrapyramidal physician's score was intercorrelated with positive and negative symptoms. Among the positive symptoms, 'conceptual disorganization' (or 'positive formal thought disorder') and 'suspiciousness/persecution' were especially correlated negatively with depression. At the post-acute phase or at the residual phase, no significant correlation between depressive and positive symptoms was found in any diagnostic subgroup. These results show the necessity of taking into account the phase of illness and the diagnostic criteria in order to study depression in schizophrenia.
本研究旨在调查抑郁症状与阳性症状之间的关系，在由三种精神分裂症诊断系统（DSMIII-R、ICD9和朗费尔特）定义的样本中，于疾病的不同阶段，使用两种阳性症状评定量表（阳性与阴性症状量表和简明精神病评定量表），并考虑阴性症状、锥体外系症状以及抗精神病药物的剂量。使用这两种量表时，在急性期的两个诊断亚组（DSMIII-R和朗费尔特）中，抑郁症状与阳性症状之间的相关性显著为负。当排除阴性症状、主观锥体外系体征和抗精神病药物剂量后，这些相关性仍然显著。只有锥体外系医生评分与阳性症状和阴性症状相互关联。在阳性症状中，“概念紊乱”（或“阳性形式思维障碍”）和“猜疑/被害妄想”与抑郁尤其呈负相关。在急性后期或残留期，在任何诊断亚组中均未发现抑郁症状与阳性症状之间存在显著相关性。这些结果表明，为了研究精神分裂症中的抑郁，有必要考虑疾病阶段和诊断标准。
