Wang B B, Müller-Immergluck M M, Austin J, Robinson N T, Chisholm A, Kenyon C
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0554.
Cell. 1993 Jul 16;74(1):29-42. doi: 10.1016/0092-8674(93)90292-x.
In insects and vertebrates, clusters of Antennapedia class homeobox (HOM-C) genes specify anteroposterior body pattern. The nematode C. elegans also contains a small cluster of HOM-C genes, one of which has been shown to specify positional identity. Here we show that two additional C. elegans HOM-C genes also specify positional identity and that together these three HOM-C genes function along the anteroposterior axis in the same order as their homologs in other organisms. Thus, HOM-C-based pattern formation has been conserved in nematodes despite the many differences in morphology and embryology that distinguish them from other phyla. Each C. elegans HOM-C gene is responsible for a distinct body region; however, where their domains overlap, two HOM-C genes can act together to specify the fates of individual cells.
在昆虫和脊椎动物中，触角足类同源异型框（HOM-C）基因簇决定了前后体轴模式。线虫秀丽隐杆线虫也含有一小簇HOM-C基因，其中一个已被证明可决定位置身份。在这里，我们表明秀丽隐杆线虫的另外两个HOM-C基因也决定位置身份，并且这三个HOM-C基因一起沿前后轴发挥作用，其顺序与其他生物中的同源基因相同。因此，尽管线虫在形态学和胚胎学上与其他门有许多差异，但基于HOM-C的模式形成在其中得以保留。每个秀丽隐杆线虫HOM-C基因负责一个独特的身体区域；然而，在它们的结构域重叠的地方，两个HOM-C基因可以共同作用来决定单个细胞的命运。
