Walker C M
Chiron Corporation, Emeryville, CA 94608.
Semin Immunol. 1993 Jun;5(3):195-201. doi: 10.1006/smim.1993.1023.
Replication of the human immunodeficiency virus (HIV) in CD4+ cells is suppressed in the presence of CD8+ cells from asymptomatic HIV-infected individuals. Although these CD8+ cells mediate HIV-specific, class I MHC restricted CTL activity, the predominant mechanism for inhibiting virus replication requires neither contact nor MHC matching between the CD8+ effector cells and CD4+ targets. Based on these data, a model involving two tiers of control on HIV replication by CD8+ cells is proposed. The first level would be mediated by a diffusible CD8+ cell-derived factor that prevents expression of the retroviral genome in a non-MHC restricted fashion. When this transcriptional control is lost, production of HIV proteins would sensitize the cell for lysis by class I MHC restricted, virus-specific CTL.
在无症状的人类免疫缺陷病毒（HIV）感染者的CD8 +细胞存在的情况下，CD4 +细胞中HIV的复制受到抑制。虽然这些CD8 +细胞介导HIV特异性、I类MHC限制性细胞毒性T淋巴细胞（CTL）活性，但抑制病毒复制的主要机制既不需要CD8 +效应细胞与CD4 +靶细胞之间的接触，也不需要MHC匹配。基于这些数据，提出了一个涉及CD8 +细胞对HIV复制进行两层控制的模型。第一层将由一种可扩散的CD8 +细胞衍生因子介导，该因子以非MHC限制的方式阻止逆转录病毒基因组的表达。当这种转录控制丧失时，HIV蛋白的产生会使细胞对I类MHC限制的、病毒特异性CTL的裂解敏感。
