Omura N, Kashiwagi H, Aoki T
Second Dept. of Surgery, Jikei University School of Medicine, Tokyo, Japan.
Scand J Gastroenterol. 1993 Jul;28(7):568-72. doi: 10.3109/00365529309096089.
To determine the effect of persistent narrowing of the gastric outlet on peptic ulcer disease, changes in gastric hormones induced by pyloric stenosis were studied in an experimental model in the rat. Pyloric stenosis was created by constricting the pylorus to a 4-mm channel. Changes in serum gastrin and plasma somatostatin concentrations, in the length of the lesser curvature, in the size of the fundic and pyloric regions, and in the G-cell and D-cell counts were determined after 4 and 8 weeks (PS4W and PS8W) and compared with those of control groups. The size of the stomach, the serum gastrin concentration, and the corrected G-cell count (indexed to stomach size) were greater in PS8W than in PS4W rats, and both were greater than in respective controls (p < 0.005). Serum somatostatin concentrations were not different, but the total D-cell count and the corrected D-cell count were higher in PS4W and PS8W rats than in controls. Moreover, the total D-cell count and the corrected D-cell count were greater in PS8W than in PS4W (p < 0.05, p < 0.005).
为了确定胃出口持续性狭窄对消化性溃疡疾病的影响，在大鼠实验模型中研究了幽门狭窄引起的胃激素变化。通过将幽门缩窄至4毫米通道来制造幽门狭窄。在4周和8周后（PS4W和PS8W）测定血清胃泌素和血浆生长抑素浓度、胃小弯长度、胃底和幽门区域大小以及G细胞和D细胞计数的变化，并与对照组进行比较。PS8W大鼠的胃大小、血清胃泌素浓度和校正后的G细胞计数（根据胃大小进行索引）均大于PS4W大鼠，且两者均大于各自的对照组（p<0.005）。血清生长抑素浓度无差异，但PS4W和PS8W大鼠的总D细胞计数和校正后的D细胞计数高于对照组。此外，PS8W的总D细胞计数和校正后的D细胞计数大于PS4W（p<0.05，p<0.005）。
