宫腔内授精与腹腔内授精治疗不孕症的随机对照研究
A randomized comparison of intrauterine and intraperitoneal insemination in the treatment of infertility.
作者信息
Gregoriou O, Papadias C, Konidaris S, Gargaropoulos A, Kalampokas E
机构信息
2nd Department of Obstetrics and Gynecology, University of Athens, Greece.
出版信息
Int J Gynaecol Obstet. 1993 Jul;42(1):33-6. doi: 10.1016/0020-7292(93)90442-y.
OBJECTIVE
To compare the pregnancy rates (PRs) between intrauterine insemination (IUI) and intraperitoneal insemination (IPI) in women receiving comparable ovarian stimulation in couples who were infertile for various infertility conditions.
METHOD
Fifty-four couples were treated. Of these, 25 were diagnosed as having unexplained infertility, 21 as having male infertility and 8 as having cervical mucus hostility.
RESULT
Nine pregnancies occurred with 89 cycles of IUI and 6 pregnancies with 85 cycles of IPI, giving an overall PR of 28%. Twelve of the 15 pregnancies occurred during the first treatment cycle and three during the second treatment cycle. There was no significant difference in the (PRs) between the IUI and IPI (P > 0.25).
CONCLUSION
Both procedures combined with superovulation proved to be simple, inexpensive safe and worthwhile for infertile couples with unexplained infertility, male infertility and cervical mucus hostility.
目的
比较在接受类似卵巢刺激的因各种不孕症而不育的夫妇中，宫腔内人工授精（IUI）和腹腔内人工授精（IPI）的妊娠率（PRs）。
方法
对54对夫妇进行治疗。其中，25例被诊断为不明原因不孕，21例为男性不育，8例为宫颈黏液抗精子抗体阳性。
结果
89个IUI周期中有9例妊娠，85个IPI周期中有6例妊娠，总体妊娠率为28%。15例妊娠中有12例发生在第一个治疗周期，3例发生在第二个治疗周期。IUI和IPI的妊娠率之间无显著差异（P>0.25）。
结论
对于不明原因不孕、男性不育和宫颈黏液抗精子抗体阳性的不育夫妇，这两种方法联合超排卵均被证明是简单、廉价、安全且值得的。
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