Michael A E, Gregory L, Walker S M, Antoniw J W, Shaw R W, Edwards C R, Cooke B A
Department of Biochemistry, Royal Free Hospital School of Medicine, London, UK.
Lancet. 1993 Sep 18;342(8873):711-2. doi: 10.1016/0140-6736(93)91710-4.
Cortisol is converted to the inactive glucocorticoid, cortisone, in several tissues by 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). We have recently measured 11 beta HSD activity in cultured human granulosa-lutein cells recovered from patients undergoing in-vitro fertilisation and embryo transfer (IVF-ET). We now report an association between the outcome of IVF-ET and 11 beta HSD activity in these cells. Of the 64 patients studied, 32 had detectable 11 beta HSD activity and none became pregnant; whereas 76% of the remaining "11 beta HSD-negative" patients achieved pregnancies. Hence 11 beta HSD activity may predict the outcome of IVF-ET.
在多个组织中，皮质醇通过11β-羟基类固醇脱氢酶（11βHSD）转化为无活性的糖皮质激素可的松。我们最近测定了从接受体外受精和胚胎移植（IVF-ET）的患者中回收的培养人颗粒黄体细胞中的11βHSD活性。我们现在报告IVF-ET的结果与这些细胞中11βHSD活性之间的关联。在研究的64例患者中，32例具有可检测到的11βHSD活性，无一例怀孕；而其余“11βHSD阴性”患者中有76%成功怀孕。因此，11βHSD活性可能预测IVF-ET的结果。
