de Gandarias J M, Irazusta J, Echevarría E, Casis L
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Life Sci. 1993;52(20):1629-32. doi: 10.1016/0024-3205(93)90044-4.
Neutral aminopeptidase activity levels during the estrous cycle and pregnancy, in the hypothalamus and the pituitary of experimental animals, was studied in this research. The cyclic stages were the estrous, diestrous and proestrous (at morning and afternoon). The pregnancy phases were the 2nd, 7th, 14th and 20th day postinsemination. The parturition day was also studied. The higher cyclic enzyme levels were found in the proestrous stage (afternoon). No differences between estrous and diestrous were observed. During pregnancy, there was a rise at 7th and 14th day, with a decrease in the 20th day. In the hypothalamus, significant increases after parturition were shown, the latter not being observed in the pituitary. In general, the changes seem to be parallel to those of the luteinizing hormone.
本研究对实验动物下丘脑和垂体在发情周期及孕期的中性氨肽酶活性水平进行了研究。发情周期阶段包括发情期、间情期和发情前期（上午和下午）。孕期阶段为授精后第2天、第7天、第14天和第20天。还对分娩日进行了研究。发情前期（下午）的循环酶水平较高。发情期和间情期未观察到差异。孕期第7天和第14天出现升高，第20天下降。在下丘脑中，分娩后显示出显著升高，而垂体中未观察到这种情况。总体而言，这些变化似乎与促黄体生成素的变化平行。
