粪肠球菌中的可传递毒素（溶血素）质粒及其对非感染性耐药性质粒的转移作用
Transmissible toxin (hemolysin) plasmid in Streptococcus faecalis and its mobilization of a noninfectious drug resistance plasmid.
作者信息
Dunny G M, Clewell D B
出版信息
J Bacteriol. 1975 Nov;124(2):784-90. doi: 10.1128/jb.124.2.784-790.1975.
Abstract
Streptococcus faecalis strain DS-5 has been shown previously to contain three plasmids, pAMalpha1, pAMbeta1, and pAMgamma1. Mixed incubation of DS-5 with strain JH2-2, a plasmid-free S. faecalis recipient, results in the transfer of pAMalpha1 (which determines resistance to tetracycline) and/or pAMgamma1. Analyses of recipients carrying various combinations of these plasmids have revealed the pAMgamma1 codes for toxin (hemolysin) production and two bacteriocin activities. JH2-2 strains carrying both pAMalpha1 and pAMgamma1, or pAMgamma1 only, can donate their plasmids to other recipients, whereas strains carrying only pAMalpha1 cannot serve as donors. This indicates that pAMgamma1 actually mobilizes the otherwise nontransferable pAMalpha1.
摘要
粪肠球菌菌株DS-5先前已被证明含有三种质粒，即pAMalpha1、pAMbeta1和pAMgamma1。将DS-5与无质粒的粪肠球菌受体菌株JH2-2混合培养，会导致pAMalpha1（决定对四环素的抗性）和/或pAMgamma1的转移。对携带这些质粒不同组合的受体菌进行分析后发现，pAMgamma1编码毒素（溶血素）的产生以及两种细菌素活性。同时携带pAMalpha1和pAMgamma1或仅携带pAMgamma1的JH2-2菌株可以将其质粒捐赠给其他受体菌，而仅携带pAMalpha1的菌株则不能作为供体菌。这表明pAMgamma1实际上能促使原本不可转移的pAMalpha1发生转移。
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