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K99菌毛与N-糖基化神经节苷脂GM3受体的多价结合。

Multivalent binding of K99 fimbriae to the N-glycolyl-GM3 ganglioside receptor.

作者信息

Willemsen P T, de Graaf F K

机构信息

Department of Molecular Microbiology, Faculty of Biology, Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Infect Immun. 1993 Oct;61(10):4518-22. doi: 10.1128/iai.61.10.4518-4522.1993.

DOI:10.1128/iai.61.10.4518-4522.1993
PMID:8104898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281193/
Abstract

The ganglioside N-glycolyl-GM3 binds laterally at numerous positions to K99 fimbriae, as shown by electron microscopic detection and erythrocyte-binding activity. The data demonstrate the multivalent nature of K99 fimbriae with respect to their receptor-binding sites.

摘要

神经节苷脂N-羟乙酰神经氨酸-GM3通过电子显微镜检测和红细胞结合活性表明，在多个位置横向结合于K99菌毛。这些数据证明了K99菌毛在其受体结合位点方面具有多价性质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/dba50bb42d85/iai00022-0508-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/ad82320a735c/iai00022-0507-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/69bc52f114c0/iai00022-0508-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/dba50bb42d85/iai00022-0508-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/ad82320a735c/iai00022-0507-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/69bc52f114c0/iai00022-0508-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5797/281193/dba50bb42d85/iai00022-0508-b.jpg

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本文引用的文献

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Infect Immun. 1984 Nov;46(2):578-84. doi: 10.1128/iai.46.2.578-584.1984.
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Carbohydrate-specific adhesion of bacteria to thin-layer chromatograms: a rationalized approach to the study of host cell glycolipid receptors.
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Enterotoxigenic Escherichia coli strains bind bovine milk gangliosides in a ceramide-dependent process.
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Lipids. 2003 Jul;38(7):761-8. doi: 10.1007/s11745-003-1124-7.
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Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution.人类中N-羟乙酰神经氨酸的缺失：机制、后果及其对灵长类动物进化的影响。
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Oral immunization with a Salmonella typhimurium vaccine vector expressing recombinant enterotoxigenic Escherichia coli K99 fimbriae elicits elevated antibody titers for protective immunity.用表达重组产肠毒素大肠杆菌K99菌毛的鼠伤寒沙门氏菌疫苗载体进行口服免疫可引发用于保护性免疫的抗体滴度升高。
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