氟马西尼和利多卡因引起的毒性：反向激动剂类型活性是否依赖昼夜节律时间？

Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?

作者信息

Bruguerolle B, Emperaire N

机构信息

Medical and Clinical Pharmacology Laboratory, Faculty of Medicine, Marseille, France.

出版信息

J Pharm Pharmacol. 1993 Jul;45(7):678-9. doi: 10.1111/j.2042-7158.1993.tb05679.x.

DOI:10.1111/j.2042-7158.1993.tb05679.x

PMID:8105070

Abstract

We have investigated the possible influence of time of day on the activity of flumazenil on lignocaine-induced toxicity in mice. The circadian pattern of the period of latency for convulsions and the induced mortality for lignocaine alone and for lignocaine plus flumazenil was not statistically significant (cosinor or analysis of variance) but the influence of flumazenil on lignocaine-induced toxicity was circadian-time dependent (F = 27.8, P = 0.0001).

摘要

我们研究了一天中的不同时间对氟马西尼作用于小鼠利多卡因诱导毒性的可能影响。单独使用利多卡因以及利多卡因加氟马西尼时，惊厥潜伏期和诱导死亡率的昼夜节律模式无统计学意义（余弦分析或方差分析），但氟马西尼对利多卡因诱导毒性的影响具有昼夜时间依赖性（F = 27.8，P = 0.0001）。