Vaille A, Balansard G, Jadot G
Laboratoire de Pharmacodynamie, Faculté de Pharmacie, Laboratoire PANMEDICA, Marseille, France.
Pharmacol Biochem Behav. 1993 Aug;45(4):791-6. doi: 10.1016/0091-3057(93)90122-a.
The compared effects of an acute and subacute treatment by fresh cola extract and caffeine on the caffeine pharmacokinetics and on cortical activities by spectral analysis of the electroencephalogram (EEG) are studied in rats. After acute cola administration, we observed an increase in half-life elimination of caffeine and a stabilization of its plasma/erythrocyte ratio. Chronic administration revealed differences in cola-caffeine penetration in erythrocytes and a reduction of the area under the curve (AUC) and plasma/erythrocyte ratio. We also noted a significant difference in the binding of the caffeine on plasma proteins after subacute administration of cola seed extract. Cola seed treatment induces an increase in the cortical activity with a widening of the dominant frequency spectrum 7- to 10-Hz band of EEG, whereas caffeine alone induces a shift of the dominant frequency band toward higher frequencies. The observed delay to obtain the greatest EEG effect related to the caffeine contained in cola seeds can be partially explained by the pharmacokinetic data.
在大鼠中研究了新鲜可乐提取物和咖啡因急性及亚急性治疗对咖啡因药代动力学以及通过脑电图（EEG）频谱分析对皮质活动的比较影响。急性给予可乐后，我们观察到咖啡因的消除半衰期增加，其血浆/红细胞比值稳定。慢性给药显示可乐 - 咖啡因在红细胞中的渗透存在差异，曲线下面积（AUC）和血浆/红细胞比值降低。我们还注意到亚急性给予可乐籽提取物后，咖啡因与血浆蛋白的结合存在显著差异。可乐籽治疗导致皮质活动增加，EEG的优势频谱7至10赫兹频段变宽，而单独使用咖啡因则导致优势频段向更高频率偏移。观察到的与可乐籽中所含咖啡因相关的获得最大EEG效应的延迟可以部分由药代动力学数据解释。
