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哮喘中的气道壁重塑:抗哮喘药物研发的新靶点。

Airway wall remodelling in asthma: a novel target for the development of anti-asthma drugs.

作者信息

Stewart A G, Tomlinson P R, Wilson J

机构信息

Microsurgery Research Centre, St Vincent's Hospital, Victoria, Australia.

出版信息

Trends Pharmacol Sci. 1993 Jul;14(7):275-9. doi: 10.1016/0165-6147(93)90130-c.

DOI:10.1016/0165-6147(93)90130-c
PMID:8105598
Abstract

The regulation of vascular smooth muscle proliferation has been examined extensively in recent years since the recognition that hyperplasia and hypertrophy of vascular smooth muscle are significant pathological features of hypertension and atherosclerosis. In this article, Alastair Stewart and colleagues discuss recent developments in the investigation of the pathology of asthma that indicate some parallels with the structural changes that occur in blood vessels in hypertension and atherosclerosis.

摘要

自从认识到血管平滑肌的增生和肥大是高血压和动脉粥样硬化的重要病理特征以来,近年来对血管平滑肌增殖的调节进行了广泛研究。在本文中,阿拉斯泰尔·斯图尔特及其同事讨论了哮喘病理学研究的最新进展,这些进展表明与高血压和动脉粥样硬化中血管发生的结构变化存在一些相似之处。

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Airway wall remodelling in asthma: a novel target for the development of anti-asthma drugs.哮喘中的气道壁重塑:抗哮喘药物研发的新靶点。
Trends Pharmacol Sci. 1993 Jul;14(7):275-9. doi: 10.1016/0165-6147(93)90130-c.
2
[Alternations of bronchial smooth muscle and effect of therapy on remodeling in asthma].[支气管平滑肌的改变及治疗对哮喘重塑的影响]
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The structural basis of airways hyperresponsiveness in asthma.哮喘气道高反应性的结构基础。
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Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo.气道壁重塑与高反应性:体内外重塑模型
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Airway smooth muscle proliferation in asthma: the potential of vascular leakage to contribute to pathogenesis.哮喘中气道平滑肌增殖:血管渗漏对发病机制的潜在影响。
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Airway remodeling: potential contributions of subepithelial fibrosis and airway smooth muscle hypertrophy/hyperplasia to airway narrowing in asthma.气道重塑:上皮下纤维化和气道平滑肌肥大/增生对哮喘气道狭窄的潜在影响。
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Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression.轻度至中度哮喘中平滑肌增生,细胞大小及基因表达无变化。
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The structural basis of airways hyperresponsiveness in asthma.哮喘气道高反应性的结构基础。
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Airway inflammation and structural changes in airway hyper-responsiveness and asthma: an overview.气道炎症与气道高反应性及哮喘中的结构变化:综述
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Airways remodelling in asthma: no doubt, no more?
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Transforming growth factor-β-induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2.成纤维细胞生长因子-2 抑制转化生长因子-β诱导的气道平滑肌细胞分化。
Am J Respir Cell Mol Biol. 2013 Mar;48(3):346-53. doi: 10.1165/rcmb.2012-0151OC. Epub 2012 Dec 13.
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Asthma, environmental risk factors, and hypertension among Arab Americans in metro Detroit.底特律都会区的美籍阿拉伯人哮喘、环境风险因素和高血压。
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Insights into early treatment of mild asthma: do inhaled corticosteroids make a difference?
轻度哮喘早期治疗的见解:吸入性糖皮质激素有作用吗?
Paediatr Drugs. 2007;9(4):219-26. doi: 10.2165/00148581-200709040-00003.
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Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling.胶原蛋白通过整合素信号传导损害气道平滑肌中的糖皮质激素作用。
Br J Pharmacol. 2006 Oct;149(4):365-73. doi: 10.1038/sj.bjp.0706881. Epub 2006 Sep 11.
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Factors controlling airway smooth muscle proliferation in asthma.哮喘中控制气道平滑肌增殖的因素。
Curr Allergy Asthma Rep. 2004 Mar;4(2):109-15. doi: 10.1007/s11882-004-0055-8.
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Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway.胶原诱导的对糖皮质激素抗增殖作用的抵抗:哮喘重塑气道中平滑肌增生的一种潜在解释。
Br J Pharmacol. 2003 Apr;138(7):1203-6. doi: 10.1038/sj.bjp.0705135.
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Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle.凝血酶对人培养气道平滑肌的蛋白酶激活受体(PAR)非依赖性生长和促炎作用。
Br J Pharmacol. 2003 Mar;138(5):865-75. doi: 10.1038/sj.bjp.0705106.
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Homologous serum increases fibronectin expression and cell adhesion in airway smooth muscle cells.
Inflammation. 1996 Aug;20(4):373-87. doi: 10.1007/BF01486740.
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The effect of glucocorticoids on proliferation of human cultured airway smooth muscle.糖皮质激素对人培养气道平滑肌增殖的影响。
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