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一项关于5%利多卡因/丙胺卡因乳膏(EMLA)用于热分解过程中局部麻醉的双盲安慰剂对照研究。

A double-blind placebo controlled study of a 5% lidocaine/prilocaine cream (EMLA) for topical anesthesia during thermolysis.

作者信息

Wagner R F, Flores C A, Argo L F

机构信息

University of Texas Medical Branch Thermolysis Clinic, Department of Dermatology, Galveston 77555-0783.

出版信息

J Dermatol Surg Oncol. 1994 Feb;20(2):148-50. doi: 10.1111/j.1524-4725.1994.tb00129.x.

Abstract

BACKGROUND

Electrolysis and thermolysis are commonly used electrosurgical methods for the permanent destruction of unwanted hair. However, patient fear of pain during treatment may interfere with or even prevent desired treatment of hirsutism on sensitive areas such as the upper lip.

OBJECTIVE

This study was conducted to assess the efficacy of EMLA (Eutetic Mixture of Local Anesthetics), a 5% lidocaine/prilocaine cream, as a topically applied local anesthetic during thermolysis on the upper lip.

METHODS

A double-blind placebo control study was conducted by the University of Texas Medical Branch thermolysis clinic. Thirty women with idiopathic hirsutism of the upper lip were studied. Pain was measured with a 100 mm visual analog scale (VAS).

RESULTS

Total paired VAS score differences comparing the placebo VAS scores to the EMLA VAS scores were significant by paired t-test (P = .0001). Adverse reactions were mild and transient.

CONCLUSION

EMLA cream may have multiple applications to the practice of dermatologic surgery, including topically achieved local anesthesia during thermolysis and electrolysis.

摘要

背景

电解法和热解法是常用于永久性去除多余毛发的电外科方法。然而,患者在治疗过程中对疼痛的恐惧可能会干扰甚至阻碍对上唇等敏感部位多毛症的理想治疗。

目的

本研究旨在评估复方利多卡因乳膏(一种5%利多卡因/丙胺卡因乳膏)作为在上唇热解过程中局部应用的局部麻醉剂的疗效。

方法

德克萨斯大学医学分部热解诊所进行了一项双盲安慰剂对照研究。研究了30名上唇特发性多毛症的女性。使用100毫米视觉模拟量表(VAS)测量疼痛。

结果

通过配对t检验,将安慰剂VAS评分与复方利多卡因乳膏VAS评分进行比较,总的配对VAS评分差异具有显著性(P = .0001)。不良反应轻微且短暂。

结论

复方利多卡因乳膏可能在皮肤科手术实践中有多种应用,包括在热解和电解过程中局部实现局部麻醉。

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