针对定义为分位数区间的VNTR等位基因的独立性检验。
Independence tests for VNTR alleles defined as quantile bins.
作者信息
Weir B S
机构信息
Department of Statistics, North Carolina State University, Raleigh 27695.
出版信息
Am J Hum Genet. 1993 Nov;53(5):1107-13.
VNTR fragment lengths in three databases maintained by the FBI for forensic purposes were partitioned into quantile bins, and tests for independence of the two bins at each of six loci were conducted. Whether independence was declared depended on the number of quantiles used. For a large number of quantile bins, equal to the number of fixed bins used by the FBI, 10 of 18 likelihood-ratio tests showed significant departures from independence when all genotypes were considered, and this changed to 7 of 18 when only heterozygotes were tested. This is in contrast to likelihood-ratio tests on fixed bins, when there were five significant departures over all genotypes and two departures for heterozygotes.
美国联邦调查局（FBI）出于法医鉴定目的维护的三个数据库中的可变数目串联重复序列（VNTR）片段长度被划分到分位数区间中，并针对六个基因座中的每一个进行了两个区间独立性的检验。是否宣布具有独立性取决于所使用的分位数数量。对于大量的分位数区间（等于FBI使用的固定区间数量），当考虑所有基因型时，18个似然比检验中有10个显示出与独立性存在显著偏差，而仅对杂合子进行检验时，这一数字变为18个中的7个。这与对固定区间进行的似然比检验形成对比，在固定区间检验中，所有基因型中有5个显著偏差，杂合子中有2个偏差。
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